Nabi – Nanomédecine, Biologie Extracellulaire, Intégratome et Innovations en Santé
NABI Laboratory: Mission and Objectives
The NABI Laboratory (Nanomedicine, Extracellular Biology, Integratome, and Health Innovations), established on January 1, 2025, by Université Paris Cité, CNRS, and INSERM, aims to develop next-generation therapeutic approaches and make them accessible to the greatest number of patients.
Through interdisciplinary research and our technology accelerator, the IVETh Bioproduction and Biotherapy Integrator, our ambition is to democratize biotherapies and de-risk their bioproduction.
Live/dead assay of fibroblasts on beads (from Léa Jabbour)
Schematic of an antero-cutaneous fistula (by Anna Sebbagh)
Co-culture of cholangiocarcinoma cells (GFP) and fibroblasts (mCherry) exposed to iron oxide nanoflowers decorated with gold NPs (by Sonia Becharef)
Schematic of an intestine affected by Crohn disease (by Anna Sebbagh)
Schematic of mesenchymal stem cells (by Anna Sebbagh)
Locomotion pattern of C. elegans (BPJ cover, JM Di Meglio)
Schematic of a mixed lymphocyte reaction assay (by Anna Sebbagh)
Schematic of an extracellular vesicle (by Anna Sebbagh)
Schematic of Atomic Force Microscopy (AFM) on polymers (by JM Di Meglio)
TEM on fibroblast exposed to Gold salts (by Giulio Avveduto).
Our Objectives
Understanding the role and fate of exogenous and endogenous nanoparticles in the body
- Investigate their properties, transformations, and impact within the organism.
- Decipher intercellular communication mechanisms involving biological nanoparticles (extracellular vesicles, viral particles, mitochondria, etc.).
Developing innovative (bio)therapies
- Leverage biological nanoparticles as therapeutic vectors in nanomedicine or as alternatives to cell therapies.
- Optimize immunotherapies and other precision treatments through external physical control.
- Overcome treatment resistance mechanisms with innovative delivery strategies.
Integrating bioproduction challenges
- Develop robust, controlled, and eco-friendly processes for the production of biological nanoparticles for therapeutic use.
- Ensure the reproducibility, safety, and scalability of manufacturing processes through AI-driven optimization for industrial and clinical transfer.
- Develop quality control methods at the nanometric scale.
Facilitating the transfer of innovations to clinical applications
- Transform scientific breakthroughs into concrete medical applications.
- Bridge the gap between fundamental research and clinical trials to directly benefit patients.
Promoting an interdisciplinary and collaborative approach
- Bring together researchers in engineering, physics, biology, medicine, chemistry, and AI for an integrated approach.
- Develop partnerships with academic institutions and industry to accelerate innovation.
Addressing global and planetary health challenges
- Contribute to disease prevention and treatment by developing safer, more effective, and more targeted therapies.
- Integrate environmental and ethical considerations into the development of nanomedicines and bioprocesses.
The NABI Laboratory is committed to pushing the boundaries of nanomedicine to make biotherapies accessible to all and to secure their large-scale production.
News
MSCmed participe à l’alliance ERDERA de recherche sur les maladies rares
L’Alliance ERDERA (European Rare Disease Research Alliance), regroupant 170 institutions, a été inaugurée début septembre 2024
Seminar – “Why have biologists from the ICE unit (VetAgro Sup Lyon) established a close collaboration with physicists for the past 15 years?”
Seminar by Pierre BRUYERE (MCU, ICE Unit, VetAgro Sup Lyon), September 24th 2024, 12pm inLavoisier A
Seminar – “The Suspended Micro-Nanochannel Resonator”
Seminar by Vincent Agache on the Tuesday, February 18th, at 12pm in Rabelais 2. Topic: "The Suspended Micro-Nanochannel Resonator"
Seminar – “Multiple Roles of Hyaluronan in Extracellular Vesicle Biology” and “Pharmacokinetics of Nanomedicines in the Eye: Implications for Extracellular Vesicle Treatments”
Seminar by Kirsi Rilla and Arto Urtti on the Tuesday, March 7th, at 12pm in Room Rabelais 2. Topic: Kirsi Rilla will discuss "Multiple Roles of Hyaluronan in Extracellular Vesicle Biology," and Arto Urtti will present on "Pharmacokinetics of Nanomedicines in the...
Seminar – “Deep Molecular Characterization of Extracellular Vesicles as Sources for Low-Invasive Indicators for Pathophysiology”
Seminar by Juan Manuel Falcon-Perez on the Tuesday, February 6th, at 12pm in Salle des thèses . Topic: "Deep Molecular Characterization of Extracellular Vesicles as Sources for Low-Invasive Indicators for Pathophysiology"
Seminar – “Therapeutic strategies for carcinomas”
Seminar by Professor Jean Paul Thiery on the Tuesday, February 27th, at 12pm in Room R229 . Topic: "Therapeutic strategies for carcinomas"
Seminar – “Genetically Encoding Multiple Functionalities into Extracellular Vesicles for the Targeted Delivery of Biologics to T Cells”
Journal Club by Panli Yu on the February 13rd, at 12pm in Salle des thèses . Article: "Genetically Encoding Multiple Functionalities into Extracellular Vesicles for the Targeted Delivery of Biologics to T Cells" by D. M. Stranford et al. 2023
Seminar – “Advances on drug delivery systems for alternative administration routes”
Seminar by Dr. Javier O. Morales on the Tuesday, March 12th, at 12 pm in room Leduc . Topic: "Advances on drug delivery systems for alternative administration routes"
Seminar – “Intérêt des vésicules extracellulaires délivrées par PIPAC dans le modèle des métastases péritonéales d’origine colique”
Seminar by Marc Pocard and Paul Rozenbaum on the Tuesday, January 23rd at 12 pm in room R229. Topic: "Intérêt des vésicules extracellulaires délivrées par PIPAC dans le modèle des métastases péritonéales d'origine colique"
Seminar – “Multidimensional Single Molecule Localization Microscopy”
Seminar by Bassam Hajj from Institut Curie on the 16th of January at 12 pm in room R229. Topic: "Multidimensional Single Molecule Localization Microscopy"
Financial supports
