Nabi
Nanomédecine, Biologie Extracellulaire, Intégratome et Innovations en Santé
NABI is a new interdisciplinary laboratory which is a spin off from MSC lab (Matière et Systèmes Complexes, Université de Paris, CNRS UMR7057). NABI was officially created on January 1st 2025, after about 7 years of settlement and growth in the building of the School of Medecine of the Université Paris-Cité. NABI is dedicated to bioengineering and translational research. NABI is located on Campus Saint Germain, 45 rue des Saints Pères (3rd floor) and affiliated to the UFR des sciences fondamentales et biomédicales, Faculté des Sciences.
NABI was started in 2018 to foster the merger of fundamental research, multidisciplinary training and entrepreneurship with the aim to promote biomedical innovation from bench to bedside. Our main goal is to envision and translate to the clinic novel diagnostic and therapeutic approaches based on nanomedicine, biotherapies and bioinspired technologies for precision medicine and personalized care. Many researchers of NABI also participate in the teaching in the masters programs of the School of Medecine and supervise many internships, from bachelor to master, and of course PhDs.
The first Director and co-founder of NABI is Florence Gazeau, Research Director at CNRS, and recently elected member of the French Academy of Sciences.
Research topics in brief
We are interested in all the physical stimuli and cues (mechanical, magnetic, electric, optical, thermodynamical stimulation, exposure to nanoparticles…) that modulate or modify the behavior of human cells and tissues during development (embryogenesis), aging and pathogenesis (cancer, inflammation, nanotoxicology…). We are looking for disruptive biomimetic treatments for regenerative medicine and cancer therapy, based on cell-derived extracellular vesicles (EVs) and other bioactive nanotherapeutics. We believe on EVs as the next generation biotherapies and as a safer and affordable alternative to cell therapies. We are also very interested in studying the fate of nanoparticles and their potential in nanotherapies.
NABI is pioneering breakthrough technologies for massive bioproduction, engineering and multimodal characterizations of extracellular vesicles and hybrid nanovectors, as well as fundamental understanding of the mechanisms of EV biogenesis and intercellular communication. NABI is the new name of Mscmed, launched in 2019, with the Region Ile de France and IDEX Université de Paris the first French EV facility and center of expertise (IVETh Core Facility) based on innovative and high-throughput bioproduction, analytical methods and data sciences to push EV-based therapy to the clinic. To this purpose, we launch a thematic group called EVOLVE.
NABI hosts two spin-off companies: EVerZom created in 2019 to develop large-scale production and engineering of clinical grade EV and Evora Biosciences to translate EV-based therapy combined to a thermoresponsive hydrogel for fistula therapy.
We are a multidisciplinary group, gathering physicists, biologists, pharmacists, chemists, data scientist, engineers and entrepreneurs.
NABI and the IVETh facility benefits from the support of Université Paris Cité, IDEX UP, CNRS, INSERM, Region Ile de France, European Union (ERC, FET-Open), and several grant agencies and foundations (ANR, INCA, ANSES, ARC, VLM…).
We are constantly looking for highly motivated and highly skilled researcher and students. Do not hesitate to contact us.
News
Lucile Alexandre lauréate du programme MEDNIGHT
Lucile Alexandre participe vendredi 14 février 2025 à la table ronde du Learning Planet Institute, 8 bis rue Charles V, 75004 Paris, sur les femmes en sciences. Lucile a également été sélectionnée pour le projet MEDNIGHT, mettant en avant les femmes scientifiques méditerranéennes.
Florence Gazeau élue à l’Académie des Sciences
Shéryl Bui Lauréate du Prix UNESCO-L’Oréal Jeunes Talents (France)
Shéryl Bui, post doc au laboratoire MSC, a reçu le prix L’Oréal UNESCO Jeunes Talents 2024, dans la mention biotechnologie pour la santé.
Seminar – « RelB Activation and Metabolic Reprogramming in Cancer Cells »
Seminar by Véronique Baud (group « NF-kB, Différenciation et Cancer », UPR7324,Université Paris Cité, IP2S), October 11st 2024, 11am, room Leduc
MSCmed participe à l’alliance ERDERA de recherche sur les maladies rares
L’Alliance ERDERA (European Rare Disease Research Alliance), regroupant 170 institutions, a été inaugurée début septembre 2024
Seminar – « Why have biologists from the ICE unit (VetAgro Sup Lyon) established a close collaboration with physicists for the past 15 years? »
Seminar by Pierre BRUYERE (MCU, ICE Unit, VetAgro Sup Lyon), September 24th 2024, 12pm inLavoisier A
Seminar – « The Suspended Micro-Nanochannel Resonator »
Seminar by Vincent Agache on the Tuesday, February 18th, at 12pm in Rabelais 2. Topic: "The Suspended Micro-Nanochannel Resonator"
Seminar – « Multiple Roles of Hyaluronan in Extracellular Vesicle Biology » and « Pharmacokinetics of Nanomedicines in the Eye: Implications for Extracellular Vesicle Treatments »
Seminar by Kirsi Rilla and Arto Urtti on the Tuesday, March 7th, at 12pm in Room Rabelais 2. Topic: Kirsi Rilla will discuss "Multiple Roles of Hyaluronan in Extracellular Vesicle Biology," and Arto Urtti will present on "Pharmacokinetics of Nanomedicines in the...
Seminar – « Deep Molecular Characterization of Extracellular Vesicles as Sources for Low-Invasive Indicators for Pathophysiology »
Seminar by Juan Manuel Falcon-Perez on the Tuesday, February 6th, at 12pm in Salle des thèses . Topic: "Deep Molecular Characterization of Extracellular Vesicles as Sources for Low-Invasive Indicators for Pathophysiology"
Seminar – « Therapeutic strategies for carcinomas »
Seminar by Professor Jean Paul Thiery on the Tuesday, February 27th, at 12pm in Room R229 . Topic: "Therapeutic strategies for carcinomas"